Newer types of therapy include plasma rich-in-platelets (PRP) and stem cell therapy. PRP has been used in several applications in medicine and surgery. These include accelerating tendon and muscle tear healing, plastic surgery, oral and maxillofacial surgery, head and neck surgery and orthopaedic surgery. Essentially, about 50-100 mls of a patient’s blood is centrifuged with reagent or passed through filters to extract a plasma component rich in platelets. It is then injected into the site of interest. PRP has been shown to possess more than 5 types of growth factors and is rich in leukocytes. Stem cell therapy is still under investigation. Stage III clinical trials have just reached their 2nd year in the US. These have the potential to reverse or at least markedly slow down early arthritis. This should be available commercially in the next few years. Patients with limited loss of joint cartilage can have it resurfaced with artificial cartilage grafts, cultured cartilage cells or even cartilage resurfacing implants. Patients younger than sixty should try to avoid a TOTAL knee replacement as further surgeries in their lifetime will be needed to replace the worn components; the results decline with increasing number of surgeries. However, in severe cases, this will be unavoidable.